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Zinc Finger Protein 645 (ZNF645)

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HAKAIL; E3 ubiquitin-protein ligase ZNF645

Zinc Finger Protein 645 (ZNF645)
CCC R608
HGNC 26371
PubMed 20657603
UniProt Q8N7E2
Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. ZNF645, restrictively expresses in normal human testes and lung cancer patients (68.3%).
CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5'-aza-2'-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 645 (ZNF645) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 645 (ZNF645) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 645 (ZNF645) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 645 (ZNF645) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 645 (ZNF645) ELISA Kit Customized Service Offer
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin."EMBO J. 31:1308-1319(2012) [PubMed] [Europe PMC] [Abstract]