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Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16)

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IDPase; Nudix Type Motif 16; U8 snoRNA-decapping enzyme; IDP phosphatase; Inosine diphosphate phosphatase; m7GpppN-mRNA hydrolase

Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16)
CCC R623
HGNC 26442
MGI 1922936
PubMed 20385596
RGD 1311387
UniProt Q96DE0
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. NUDT16, as an inosine triphosphate (ITP)/xanthosine triphosphate (XTP)/GTP-binding protein. Recombinant NUDT16 hydrolyzes purine nucleoside diphosphates to the corresponding nucleoside monophosphates. NUDT16 is mostly localized in the nucleus, and especially in the nucleolus. Knockdown of NUDT16 in HeLa MR cells caused cell cycle arrest in S-phase, reduced cell proliferation, increased accumulation of single-strand breaks in nuclear DNA as well as increased levels of inosine in RNA.NUDT16 is a (deoxy)inosine diphosphatase that may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 16 (NUDT16) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme."Mol. Cell 13:817-828(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)."J. Biol. Chem. 282:24792-24805(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme."Nucleic Acids Res. 36:6021-6034(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Multiple mRNA decapping enzymes in mammalian cells."Mol. Cell 40:423-432(2010) [PubMed] [Europe PMC] [Abstract]
  9. "NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest."Nucleic Acids Res. 38:4834-4843(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA."Protein Cell 2:64-73(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystallization and crystallographic analysis of human NUDT16."Acta Crystallogr. F 64:639-640(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human nudix motif 16 (NUDT16)."Submitted (FEB-2009) to the PDB data bank
  15. "Crystal structure of human NUDT16 in complex with IMP and magnesium."Submitted (NOV-2010) to the PDB data bank