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ATP/GTP Binding Protein Like Protein 1 (AGBL1)

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CCP4; Cytosolic Carboxypeptidase 4

ATP/GTP Binding Protein Like Protein 1 (AGBL1)
CCC R631
HGNC 26504
MGI 3646469
PubMed 24094747
RGD 1560280
UniProt Q96MI9
AGBL1, Belongs to the peptidase M14 family. In brain, Nna1/CCP1, CCP5, and CCP6 are broadly distributed, whereas CCP2 and 3 exhibit restricted patterns of expression. Nna1/CCP1, CCP2, CCP5, and CCP6 were found to exhibit a cytosolic distribution, with a slight accumulation of CCP5 in the nucleus.
Nna1/CCP1 and CCP2–6 function in the processing of cytosolic proteins such as alpha-tubulin, which is known to be modified by the removal of a C-terminal tyrosine. Analysis of the forms of alpha tubulin in the olfactory bulb of mice lacking Nna1/CCP1 showed the absence of the detyrosinylated form in the mitral cells. Taken together, these results are consistent with a role for Nna1/CCP1 and the related CCPs in the processing of tubulin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 1 (AGBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 1 (AGBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 1 (AGBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 1 (AGBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 1 (AGBL1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4."Am. J. Hum. Genet. 93:758-764(2013) [PubMed] [Europe PMC] [Abstract]