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Adenylate Kinase 8 (AK8)

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C9orf98; ATP-AMP transphosphorylase 8

Adenylate Kinase 8 (AK8)
CCC R636
HGNC 26526
MGI 1916120
RGD 1303144
UniProt Q96MA6
AK8 is the second known human AK with two complete and active AK domains within its polypeptide chain, a feature that previously was shown also for AK5.
The full length AK8, as well as its two domains AK8p1 and AK8p2, all showed similar AK enzyme activity. AK7, full length AK8, AK8p1 and AK8p2 phosphorylated AMP, CMP, dAMP and dCMP with ATP as phosphate donor and also AMP, CMP and dCMP with GTP as phosphate donor. Both AK7 and the full length AK8 showed highest affinity for AMP with ATP as phosphate donor and proved to be more efficient in AMP phosphorylation as compared to the major cytosolic isoform AK1. Expression of the proteins fused with the green fluorescent protein demonstrated a cytosolic localization for both AK7 and AK8.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenylate Kinase 8 (AK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenylate Kinase 8 (AK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylate Kinase 8 (AK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylate Kinase 8 (AK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylate Kinase 8 (AK8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenylate Kinase 8 (AK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenylate Kinase 8 (AK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylate Kinase 8 (AK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylate Kinase 8 (AK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylate Kinase 8 (AK8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenylate Kinase 8 (AK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenylate Kinase 8 (AK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylate Kinase 8 (AK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylate Kinase 8 (AK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylate Kinase 8 (AK8) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes."Biochem. J. 433:527-534(2011) [PubMed] [Europe PMC] [Abstract]
  5. "The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase."Int. J. Biochem. Cell Biol. 45:925-931(2013) [PubMed] [Europe PMC] [Abstract]