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Mixed Lineage Kinase Domain Like Protein (MLKL)

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Mixed Lineage Kinase Domain Like Protein (MLKL)
CCC R645
HGNC 26617
MGI 1921818
PubMed 24012422
RGD 1592221
UniProt Q8NB16
MLKL, Belongs to the protein kinase superfamily. The protein kinase domain is predicted to be catalytically inactive. Protein kinases are critical modulators in the signal pathway of tumor cells and therefore a suitable object of drug development using inhibitors for such kinases. Sequence analysis of MLKL identified a kinase domain within the C-terminus of the protein. Further data support the idea that MLKL specifically can regulate more than one signaling pathway. However, the specific function of MLKL was not known yet.
The apoptotic activity of MLKL was in fact higher compared to known tumor suppressors such as CDKN1A, PTEN, TP53, or MYC. These findings suggest MLKL as a new target for cancer diagnostic and/or therapy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mixed Lineage Kinase Domain Like Protein (MLKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Polyclonal Antibody Customized Service Offer
Assay Kits SER645Hu ELISA Kit for Mixed Lineage Kinase Domain Like Protein (MLKL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mixed Lineage Kinase Domain Like Protein (MLKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mixed Lineage Kinase Domain Like Protein (MLKL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mixed Lineage Kinase Domain Like Protein (MLKL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mixed Lineage Kinase Domain Like Protein (MLKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mixed Lineage Kinase Domain Like Protein (MLKL) Polyclonal Antibody Customized Service Offer
Assay Kits SER645Ra ELISA Kit for Mixed Lineage Kinase Domain Like Protein (MLKL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The protein kinase complement of the human genome."Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase."Cell 148:213-227(2012) [PubMed] [Europe PMC] [Abstract]
  11. "The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."Cell 148:228-243(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis."Proc. Natl. Acad. Sci. U.S.A. 109:5322-5327(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis."Nat. Cell Biol. 16:55-65(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL."Biochem. J. 457:369-377(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural insights into RIP3-mediated necroptotic signaling."Cell Rep. 5:70-78(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]