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Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6)

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SAMD6; ANKRD14; SamCystin; PKDR1; Sterile Alpha Motif Domain Containing 6; Ankyrin Repeat Domain 14

Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6)
CCC R662
HGNC 26724
MGI 1922941
PubMed 23793029
RGD 3334
UniProt Q68DC2
The PKD/Mhm(cy/+) rat is a widely used animal model for the study of human autosomal dominant polycystic kidney disease, one of the most common genetic disorders, affecting one in 1000 individuals. Anks6 is mutated and cystogenesis is still lacking, and the function of Anks6 is presently unknown. This study presents a novel transgenic rat model that overexpresses the mutated 2.8-kb Anks6 cDNA in the renal tubular epithelium. The transgenic Anks6 acts in a dominant-negative fashion and causes a predictable polycystic phenotype that largely mimics the general characteristics of the PKD/Mhm(cy/+) rats. Cyst development is accompanied by enhanced c-myc expression and continuous proliferation, apoptosis, and de-differentiation of the renal tubular epithelium as well as by a lack of translational up-regulation of p21 during aging.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat And Sterile Alpha Motif Domain Containing Protein 6 (ANKS6) ELISA Kit Customized Service Offer
  1. "Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat."J. Am. Soc. Nephrol. 16:3517-3526(2005) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat."Eur. J. Med. Genet. 51:325-331(2008) [PubMed] [Europe PMC] [Abstract]
  10. "ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3." Nat. Genet. 45:951-956(2013) [PubMed] [Europe PMC] [Abstract]