Serine/Arginine Repetitive Matrix Protein 3 (SRRM3)

SRRM3, Belongs to the CWC21 family. Cwc21 is a 135 amino acid yeast protein that shares homology with the N-terminal domain of human SRm300/SRRM2, a large serine/arginine-repeat protein shown previously to associate with the splicing coactivator and 3'-end processing stimulatory factor, SRm160.

Proteomic analysis of spliceosomal complexes has suggested a role for Cwc21 and SRm300 at the core of the spliceosome. However, specific functions for these proteins have remained elusive. Combined data from these assays support multiple roles for Cwc21 in the formation and function of splicing complexes.