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PAP Associated Domain Containing Protein 4 (PAPD4)

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GLD2; TUTase2; RET2; Terminal Uridylyl Transferase 2; Terminal Uridylyltransferase 2

PAP Associated Domain Containing Protein 4 (PAPD4)
CCC R670
HGNC 26776
MGI 2140950
PubMed 23700402
RGD 1306438
UniProt Q6PIY7
TUTase2 performs the guide RNA (gRNA) directed addition of U residues to single stranded (ss) mRNA. RET2 addition of U residues to the 3’ end of pre-cleaved mRNA (mRNA/gRNA duplex) is also responsible for promoting re-ligation of the cleaved mRNA substrate by RNA editing ligase 2 (REL2).
RET2 interacts with the protein MP81 (KEPA1), which also serves to couple RET2 to the REL2 ligase. The enzyme utilizes three positively charged amino acid residues for the recognition and binding of ssRNA substrates. The ribose sugar of UTPs is recognized by residues from both the N-terminal and C-terminal domains. Uridine base specificity is conveyed by base stacking interactions with Y319 along with hydrogen bonding to N277 and a coordinated water .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAP Associated Domain Containing Protein 4 (PAPD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAP Associated Domain Containing Protein 4 (PAPD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAP Associated Domain Containing Protein 4 (PAPD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAP Associated Domain Containing Protein 4 (PAPD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAP Associated Domain Containing Protein 4 (PAPD4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mammalian GLD-2 homologs are poly(A) polymerases."Proc. Natl. Acad. Sci. U.S.A. 101:4407-4412(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Vertebrate GLD2 poly(A) polymerases in the germline and the brain."RNA 11:1117-1130(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]