TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1)

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P53CSV; WF-1; p53CSV; p53-Inducible Cell-Survival Factor

TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1)
Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not fully understood. p53CSV contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced apoptosis, whereas overexpression protected cells from apoptosis caused by DNA damage. p53CSV is induced significantly when cells have a low level of genotoxic stresses, but not when DNA damage is severe. p53CSV can modulate apoptotic pathways through interaction with Hsp70 that probably inhibits activity of apoptosis protease activating factor-1. Under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53 Regulated Inhibitor Of Apoptosis 1 (TRIAP1) ELISA Kit Customized Service Offer
  1. "p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway."Cancer Res. 65:1197-1206(2005) [PubMed] [Europe PMC] [Abstract]
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  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid."Cell Metab. 18:287-295(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]