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PDZ Domain Containing Protein 8 (PDZD8)

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PDZK8; Sarcoma antigen NY-SAR-84/NY-SAR-104

PDZ Domain Containing Protein 8 (PDZD8)
CCC R706
HGNC 26974
MGI 2677270
PubMed 21549406
RGD 1308622
UniProt Q8NEN9
PDZD8 is a novel Gag-interacting factor that promotes retroviral infection. In a yeast two-hybrid screen for cellular factors that could interact with human immunodeficiency virus type 1 (HIV-1) Gag protein, identified PDZD8 and confirmed the interaction by coimmunoprecipitation (co-IP).
PDZD8 overexpression promoted the initiation of reverse transcription and increased infection by pseudotyped retroviruses independent of the route of viral entry, while transient knockdown of endogenous levels decreased HIV-1 infection. A mutant of PDZD8 lacking a predicted coiled-coil domain in its Gag-interacting region failed to bind Gag and promote HIV-1 infection, identifying the domain of PDZD8 required for mediating these effects.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 8 (PDZD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 8 (PDZD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 8 (PDZD8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 8 (PDZD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 8 (PDZD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 8 (PDZD8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing Protein 8 (PDZD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing Protein 8 (PDZD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing Protein 8 (PDZD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing Protein 8 (PDZD8) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Immunomic analysis of human sarcoma."Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "PDZD8 is a novel Gag-interacting factor that promotes retroviral infection."J. Virol. 84:8990-8995(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  9. "PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1."Virology 415:114-121(2011) [PubMed] [Europe PMC] [Abstract]