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Neuropeptide Q (NPQ)

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SPX; C12orf39; Spexin

Neuropeptide Q (NPQ)
CCC R776
HGNC 28139
MGI 2442262
PubMed 22038051
RGD 1587448
UniProt Q9BT56
C12ORF39 contains a typical amidation/proteolytic processing signal (Gly-Arg-Arg motif). Interestingly, C12ORF39 protein is not hydrolysed, but is a full-length protein without signal peptides. c-Myc-tagged C12ORF39 is secreted into culture medium in transfected HeLa cells.c12orf39 is mainly expressed in placenta and brain. Immunohistochemistry on formalin-fixed paraffin-embedded human term placenta using a rabbit antibody against human C12ORF39 demonstrated that the protein was localized extracellularly, surrounding the trophoblastic cells.C12ORF39 secretion could be blocked by brefeldin A, suggesting that the secretion of C12ORF39 is dependent on the Golgi apparatus.C12ORF39 protein co-localized with the Golgi apparatus. C12ORF39 is not a secreted small peptide, it can also be secreted to play a role in the biological functions of the placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR776Hu01 Recombinant Neuropeptide Q (NPQ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Neuropeptide Q (NPQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropeptide Q (NPQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropeptide Q (NPQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropeptide Q (NPQ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuropeptide Q (NPQ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuropeptide Q (NPQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropeptide Q (NPQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropeptide Q (NPQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropeptide Q (NPQ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuropeptide Q (NPQ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuropeptide Q (NPQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuropeptide Q (NPQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuropeptide Q (NPQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuropeptide Q (NPQ) ELISA Kit Customized Service Offer
  1. "Evolutionary sequence modeling for discovery of peptide hormones."PLoS Comput. Biol. 5:E1000258-E1000258(2009) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of novel peptide hormones in the human proteome by hidden Markov model screening."Genome Res. 17:320-327(2007) [PubMed] [Europe PMC] [Abstract]
  5. "C12ORF39, a novel secreted prot ein with a typical amidation processing signal."Biosci. Rep. 30:1-10(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Spexin is expressed in the carotid body and is upregulated by postnatal hyperoxia exposure."Adv. Exp. Med. Biol. 758:207-213(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception."FASEB J. 26:947-954(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity."Obesity 22:1643-1652(2014) [PubMed] [Europe PMC] [Abstract]