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5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL)

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AGXT2L2; Alanine Glyoxylate Aminotransferase 2 Like Protein 2

5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL)
CCC R798
HGNC 28249
MGI 1920197
PubMed 23242558
UniProt Q8IUZ5
AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis.
AGXT2L2 is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Phosphohydroxy L-Lysine Phospho Lyase (PHYKPL) ELISA Kit Customized Service Offer
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine."J. Biol. Chem. 287:7246-7255(2012) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the AGXT2L2 gene cause phosphohydroxylysinuria."J. Inherit. Metab. Dis. 36:961-966(2013) [PubMed] [Europe PMC] [Abstract]