Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1)
[Edit]Transaminase A-like protein 1; Putative aspartate aminotransferase, cytoplasmic 2
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GOT1L1 is a 421 amino acid member of the class-I pyridoxal-phosphate-dependent aminotransferase family. Similar to glutamate-oxaloacetate transaminase (GOT1), GOT1L1 is found primarily as a homodimer in the cytoplasmic space but also has mitochondrial and chloroplastic isozymes. GOT1L1 transaminates 2-oxoglutarate with L-aspartate to yield oxaloacetate and L-glutamate. This reaction requires a pyridoxal phosphate cofactor to occur. The GOT1L1 peptidase is predominately expressed in the liver and serum levels of this protein can be used as an indicator of liver disease. Also, elevated glutamate concentrations in the brain interstitial fluids can lead to pathological brain conditions. The glutamate-scavenging properties of these aminotranferase type enzymes likely prevent glutamate excitotoxicity and the long-lasting neurological deficits seen after stroke.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Glutamic Oxaloacetic Transaminase 1 Like Protein 1 (GOT1L1) | ELISA Kit Customized Service Offer |
- "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]