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Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3)

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SCCRO3; DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3; Squamous cell carcinoma-related oncogene 3

Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3)
CCC R878
HGNC 28734
MGI 2679003
PubMed 23201271
RGD 1308893
UniProt Q8IWE4
DCUN1D3 was found during the process of high throughput screening of novel human genes associated with serum response element (SRE) pathway activation. The DCUN1D3 gene is highly conserved among vertebrates. Human DCUN1D3 complementary DNA (cDNA) encodes 304 amino acids with an apparent molecular mass of 34 kDa.
DCUN1D3 was broadly expressed in several tumor tissues and cultured cell lines; however, UVC irradiation of different doses significantly increased DCUN1D3 expression level in these cancer cell lines. DCUN1D3 localized mainly in the cytoplasm and perinuclear, but after UVC treatment, the DCUN1D3 gradually entered the nucleus. DCUN1D3 is a novel UVC-response gene involved in cell cycle regulation and cell survival.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defective In Cullin Neddylation 1, Domain Containing Protein 3 (DCUN1D3) ELISA Kit Customized Service Offer
  1. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)."J. Biol. Chem. 289:34728-34742(2014) [PubMed] [Europe PMC] [Abstract]
  5. "Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes."Structure 21:42-53(2013) [PubMed] [Europe PMC] [Abstract]