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Coordinator Of PRMT5 And Differentiation Stimulator (COPRS)

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COPR5; TTP1; C17orf79; Cooperator Of PRMT5

Coordinator Of PRMT5 And Differentiation Stimulator (COPRS)
CCC R890
HGNC 28848
MGI 1913673
RGD 1565675
UniProt Q9NQ92
COPR5 tightly binds to PRMT5, both in vitro and in living cells, but not to other members of the PRMT family. PRMT5 bound to COPR5 methylates histone H4 (R3) preferentially when compared with histone H3 (R8), suggesting that COPR5 modulates the substrate specificity of nuclear PRMT5-containing complexes, at least towards histones. Markedly, recombinant COPR5 binds to the amino terminus of histone H4 and is required to recruit PRMT5 to reconstituted nucleosomes in vitro. Consistently, COPR5 depletion in cells strongly reduces PRMT5 recruitment on chromatin at the PRMT5 target gene cyclin E1 (CCNE1) in vivo. Moreover, both COPR5 depletion and overexpression affect CCNE1 promoter expression. COPR5 is an important chromatin adaptor for PRMT5 to function on a subset of its target genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR890Hu01 Recombinant Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR890Hu21 Monoclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) WB; IHC; ICC; IP.
PAR890Hu01 Polyclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) WB; IHC; ICC; IP.
Assay Kits SER890Hu ELISA Kit for Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coordinator Of PRMT5 And Differentiation Stimulator (COPRS) ELISA Kit Customized Service Offer
  1. "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions."Genomics 66:93-97(2000) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (JUL-2007) to UniProtKB
  5. "The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5."EMBO Rep. 9:452-458(2008) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]