≡

Tel2 Interacting Protein 1 (TTI1)

[Edit]

SMG10; TELO2-interacting protein 1 homolog

Tel2 Interacting Protein 1 (TTI1)
CCC R925
HGNC 29029
MGI 1922675
PubMed 20427287
RGD 1562582
UniProt O43156
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. Tti1 constitutively interacts with mTOR in both mTORC1 and mTORC2.
Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt) and also induces autophagy. S. pombe Tti1 binds to Tel2, a protein whose mammalian homolog was recently reported to regulate the stability of PIKKs. Tti1 binds to Tel2 also in mammalian cells, and Tti1 interacts with and stabilizes all six members of the PIKK family of . These results indicate that Tti1 and Tel2 are important not only for mTOR stability but also for assembly of the mTOR complexes to maintain their activities.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tel2 Interacting Protein 1 (TTI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tel2 Interacting Protein 1 (TTI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tel2 Interacting Protein 1 (TTI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tel2 Interacting Protein 1 (TTI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tel2 Interacting Protein 1 (TTI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tel2 Interacting Protein 1 (TTI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tel2 Interacting Protein 1 (TTI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tel2 Interacting Protein 1 (TTI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tel2 Interacting Protein 1 (TTI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tel2 Interacting Protein 1 (TTI1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly."J. Biol. Chem. 285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability."Genes Dev. 24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
  9. "AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay."Sci. Signal. 3:RA27-RA27(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma."Nat. Cell Biol. 15:72-81(2013) [PubMed] [Europe PMC] [Abstract]