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GDP Mannose Pyrophosphorylase A (GMPPA)

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GTP-mannose-1-phosphate guanylyltransferase alpha; Mannose-1-phosphate guanyltransferase alpha

GDP Mannose Pyrophosphorylase A (GMPPA)
CCC R940
HGNC 22923
MGI 1916330
PubMed 24035193
RGD 1560644
UniProt Q96IJ6
GMPPA is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides.
GDP-mannose pyrophosphorylase (GMPP) catalyses the synthesis of GDP-mannose, which is the precursor for the mannose residues in glycoconjugates, using mannose 1-phosphate and GTP as substrates. Repression of GMPP in yeast leads to phenotypes including cell lysis, defective cell wall, and failure of polarized growth and cell separation. A prerequisite for the synthesis of these molecules is the availability of the activated mannose donor, GDP-Man, the product of the catalysis of mannose-1-phosphate and GTP by GDP-mannose pyrophosphorylase (GDP-MP).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase A (GMPPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase A (GMPPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase A (GMPPA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase A (GMPPA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase A (GMPPA) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in GMPPA cause a glycosylation disorder characterized by intellectual disability and autonomic dysfunction." Am. J. Hum. Genet. 93:727-734(2013) [PubMed] [Europe PMC] [Abstract]