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Centrosomal Protein 164kDa (CEP164)

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NPHP15

Centrosomal Protein 164kDa (CEP164)
CCC R959
HGNC 29182
MGI 2384878
PubMed 17954613
RGD 1561243
UniProt Q9UPV0
Wiki CEP164
Cep164, a novel centriole appendage protein required for primary cilium formation. Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. Cep164, was indispensable for PC formation and hence characterized in detail. Cep164 could be localized to the distal appendages of mature centrioles. In contrast to ninein and Cep170, two components of subdistal appendages, Cep164 persisted at centrioles throughout mitosis. The localizations of Cep164 and ninein/Cep170 were mutually independent during interphase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 164kDa (CEP164) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 164kDa (CEP164) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 164kDa (CEP164) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 164kDa (CEP164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 164kDa (CEP164) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 164kDa (CEP164) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 164kDa (CEP164) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 164kDa (CEP164) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 164kDa (CEP164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 164kDa (CEP164) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 164kDa (CEP164) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 164kDa (CEP164) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 164kDa (CEP164) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 164kDa (CEP164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 164kDa (CEP164) ELISA Kit Customized Service Offer
  1. "Cep164, a novel centriole appendage protein required for primary cilium formation."J. Cell Biol. 179:321-330(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1."Genes Dev. 22:587-600(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  9. "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity."Cell Cycle 8:655-664(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy."Cytoskeleton 68:619-627(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling." Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Centriole distal appendages promote membrane docking, leading to cilia initiation."Genes Dev. 27:163-168(2013) [PubMed] [Europe PMC] [Abstract]
  13. "CCDC41 is required for ciliary vesicle docking to the mother centriole."Proc. Natl. Acad. Sci. U.S.A. 110:5987-5992(2013) [PubMed] [Europe PMC] [Abstract]