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Centrosomal Protein 152kDa (CEP152)

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Centrosomal Protein 152kDa (CEP152)
CCC R980
HGNC 29298
MGI 2139083
PubMed 21059844
RGD 1305348
UniProt O94986
Wiki CEP152
CEP152 is a core protein of the centrosome, a major microtubule-organizing center of animal cells that influences cell shape, polarity, and motility, and has a crucial function in cell division.
The transcript contains a repetitive element in its 3-prime end, and the deduced 1,209-amino acid protein shares significant similarity with Xenopus Numa protein (NUMA1). CEP152 in all tissues examined, with highest expression in brain, lung, kidney, pancreas, testis, and ovary, and lowest expression in spleen.The deduced protein contains 8 coiled-coil domains and has a calculated molecular mass of 151.5 kD. Fluorescence-tagged CEP152 associated with centrosomes in transfected U2OS cells, and salt extraction experiments revealed that it is a core centrosomal protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 152kDa (CEP152) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 152kDa (CEP152) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 152kDa (CEP152) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 152kDa (CEP152) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 152kDa (CEP152) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 152kDa (CEP152) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 152kDa (CEP152) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 152kDa (CEP152) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 152kDa (CEP152) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 152kDa (CEP152) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 152kDa (CEP152) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 152kDa (CEP152) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 152kDa (CEP152) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 152kDa (CEP152) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 152kDa (CEP152) ELISA Kit Customized Service Offer
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  5. "Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome."J. Cell Biol. 191:731-739(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Asterless is a scaffold for the onset of centriole assembly."Nature 467:714-718(2010) [PubMed] [Europe PMC] [Abstract]
  7. "CEP152 is a genome maintenance protein disrupted in Seckel syndrome." Nat. Genet. 43:23-26(2011) [PubMed] [Europe PMC] [Abstract]
  8. "A primary microcephaly protein complex forms a ring around parental centrioles."Nat. Genet. 43:1147-1153(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4." Am. J. Hum. Genet. 87:40-51(2010) [PubMed] [Europe PMC] [Abstract]
  10. "A Japanese-specific allele in the GALNT11 gene."Leg. Med. 12:208-211(2010) [PubMed] [Europe PMC] [Abstract]