≡

KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2)

[Edit]

SIP; MXRA3; ANKRD25; Matrix-Remodelling Associated 3; Ankyrin Repeat Domain 25; SRC-1-interacting protein

KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2)
CCC R981
HGNC 29300
MGI 2384568
UniProt Q63ZY3
Wiki ANKRD25
The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank.
A new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and phylogenetic analyses. Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and immunostaining at the protein level. Kank family genes showed variations in the expression level among tissues and kidney cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for KN Motif And Ankyrin Repeat Domains Protein 2 (KANK2) ELISA Kit Customized Service Offer
  1. "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm."EMBO J. 26:2645-2657(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of novel podocyte-associated proteins sult1b1 and ankrd25."Nephron Exp. Nephrol. 117:E39-E46(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria."J. Biol. Chem. 287:12612-12621(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair."J. Med. Genet. 51:388-394(2014) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of KANK2 ankyrin repeats."Submitted (DEC-2012) to the PDB data bank