≡

Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3)

[Edit]

NEZHA

Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3)
CCC R983
HGNC 29307
MGI 1916947
PubMed 23169647
UniProt Q9P1Y5
The deduced 1,253-amino acid human Nezha protein contains an N-terminal calponin homology domain, 2 central coiled-coil regions, and a C-terminal DUF1781 domain. Western blot analysis of human Caco2 cells detected major and minor Nezha proteins with apparent molecular masses of 150 and 160 kD, respectively. Immunofluorescence analysis of Caco2 cells revealed Nezha in a punctate distribution within the cytoplasm. It also localized along the zonula adherens, but only in mature cell-cell contacts.Nezha bound microtubules at their minus ends and tethered them to the zona adherens. The minus end-directed motor protein KIFC3 concentrated at the zona adherens in a manner dependent upon PLEKHA7, Nezha, and microtubules, and depletion of any of these proteins resulted in disorganized zona adherens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calmodulin Regulated Spectrin Associated Protein 3 (CAMSAP3) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts."Cell 135:948-959(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules."Proc. Natl. Acad. Sci. U.S.A. 109:20029-20034(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]