Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1)
[Edit]RASGEF2; C10orf23; VKIND; RasGEF Domain Family, Member 2; KIND Containing 1; Protein very KIND; Cerebral protein 9
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RasGEF presents several phylogenetic groups with missing genes in some. For example, RasGRP and PLCE1 are missing in insects, while KNDC1 is only present in mammals. Other RasGEF and overall Ras groups are related to large speciation processes affecting whole species clades, such as: RasGRP, PLCE1, and KNDC1 groups in the RasGEF family; and RERG, RASL11, REM/RRAD, Rasl12, ERAS, SRS, and RGK groups in the Ras family.
The is only present in mammals and is expressed in the brain, with a high abundance in the cerebellum that is restricted to the Purkinje cells . KNDC1 controls dendrite growth, by linking Ras with Map2, a protein that is associated with microtubules . The functional role of KNDC1 genes seem to relate this specific divergent phylogenetic group to brain evolution in mammals.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinase Non Catalytic-C-Lobe Domain Containing Protein 1 (KNDC1) | ELISA Kit Customized Service Offer |
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- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]