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Retention In Endoplasmic Reticulum 1 (RER1)

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Retention In Endoplasmic Reticulum 1 (RER1)
CCC S129
HGNC 30309
MGI 1915080
PubMed 21187406
RGD 1306324
UniProt O15258
RER1 is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. Human Rer1 protein was expressed in HeLa cells and the subcellular distribution analyzed by double immunofluorescence and immunoelectron microscopy of thawed cryosections. The tagged protein was localized to the Golgi apparatus and peripheral elements of the ER-Golgi interface. High overexpression leads to relocation of human Rer1 to ER-like structures together with KDEL-receptor and affects the structural organization of the Golgi apparatus. Under conditions of brefeldin A treatment, human Rer1 distributes together with recycling Golgi proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retention In Endoplasmic Reticulum 1 (RER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retention In Endoplasmic Reticulum 1 (RER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retention In Endoplasmic Reticulum 1 (RER1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retention In Endoplasmic Reticulum 1 (RER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retention In Endoplasmic Reticulum 1 (RER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retention In Endoplasmic Reticulum 1 (RER1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retention In Endoplasmic Reticulum 1 (RER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retention In Endoplasmic Reticulum 1 (RER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retention In Endoplasmic Reticulum 1 (RER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retention In Endoplasmic Reticulum 1 (RER1) ELISA Kit Customized Service Offer
  1. "Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae."Eur. J. Cell Biol. 74:31-40(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]