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RNA Polymerase III, DNA Directed Polypeptide B (POLR3B)

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RPC2; C128; DNA-directed RNA polymerase III subunit RPC2; DNA-directed RNA polymerase III 127.6 kDa polypeptide

RNA Polymerase III, DNA Directed Polypeptide B (POLR3B)
CCC S132
HGNC 30348
MGI 1917678
PubMed 22036171
RGD 1565311
UniProt Q9NW08
POLR3B is a 1,133 amino acid protein that localizes to the nucleus and belongs to the RNA polymerase β chain family. Existing as the second largest component of the multi-protein RNA polymerase III (Pol III) complex, POLR3B functions as a DNA-dependent RNA polymerase that specifically catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. The gene encoding POLR3B maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide B (POLR3B) ELISA Kit Customized Service Offer
  1. "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."Mol. Cell. Biol. 22:8044-8055(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."Cell 138:576-591(2009) [PubMed] [Europe PMC] [Abstract]
  6. "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate."Nat. Immunol. 10:1065-1072(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy."Am. J. Hum. Genet. 89:644-651(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy."Am. J. Hum. Genet. 89:652-655(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism."J. Med. Genet. 50:194-197(2013) [PubMed] [Europe PMC] [Abstract]