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Glycine-N-Acyltransferase Like Protein 1 (GLYATL1)

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GNAT; Glutamine N-acyltransferase; Acyl-CoA:glycine N-acyltransferase-like protein 1

Glycine-N-Acyltransferase Like Protein 1 (GLYATL1)
CCC S168
HGNC 30519
UniProt Q969I3
The glycine-N-acyltransferase (GLYAT) is well known to be involved in thedetoxification of endogenous and exogenous xenobiotic acyl-CoA's in mammals.GLYATL1 was1546 base pairs in length and contained an open reading frame (ORF) encoding apolypeptide of 302 amino acids. GLYATL1 was a split gene that was consisted of 7 exonsand 6 introns and mapped to chromosome 11q12.1. The expression of GLYATL1 could befound in liver, kidney, pancreas, testis, ovary and stomach among 18 human tissues by RT-PCR analysis. Subcellular localization of myc-tagged GLYATL1 fusion protein revealedthat GLYATL1 was distributed primarily in the cytoplasm of COS-7 cells. Furthermore,through the pathway profiling assay, the GLYATL1 protein was found to activate HSEsignaling pathway in a dose-dependent manner when overexpressed in HEK293T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycine-N-Acyltransferase Like Protein 1 (GLYATL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycine-N-Acyltransferase Like Protein 1 (GLYATL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycine-N-Acyltransferase Like Protein 1 (GLYATL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycine-N-Acyltransferase Like Protein 1 (GLYATL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycine-N-Acyltransferase Like Protein 1 (GLYATL1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel human glycine-n-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway."Int. J. Mol. Sci. 8:433-444(2008)
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma."Biochem. Biophys. Res. Commun. 420:901-906(2012) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]