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Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins.
ZNF519is a 540 amino acid nuclear protein that contains one KRAB domain and ten C2H2-type zinc fingers. The gene encoding ZNF519 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases, representing about 2.5% of total DNA in cells. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Zinc Finger Protein 519 (ZNF519) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Zinc Finger Protein 519 (ZNF519) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Zinc Finger Protein 519 (ZNF519) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Zinc Finger Protein 519 (ZNF519) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Zinc Finger Protein 519 (ZNF519) | ELISA Kit Customized Service Offer |
- "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]