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Tax Interaction Protein 1 (TIP1)

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TAX1BP3; Tax1 (T-Cell Leukemia Virus Type I) Binding Protein 3; Tax-interacting protein 1; Glutaminase-interacting protein 3

Tax Interaction Protein 1 (TIP1)
CCC S188
HGNC 30684
MGI 1923531
PubMed 20498706
UniProt O14907
Wiki TAX1BP3
Tax1-binding protein 3 is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV)which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol. May play a role in the Rho signaling pathway. May act as an inhibitor of the Wnt signaling pathway. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tax Interaction Protein 1 (TIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tax Interaction Protein 1 (TIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tax Interaction Protein 1 (TIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tax Interaction Protein 1 (TIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tax Interaction Protein 1 (TIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tax Interaction Protein 1 (TIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tax Interaction Protein 1 (TIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tax Interaction Protein 1 (TIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tax Interaction Protein 1 (TIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tax Interaction Protein 1 (TIP1) ELISA Kit Customized Service Offer
  1. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract].
  2. "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins."FEBS Lett. 488:116-122(2001) [PubMed] [Europe PMC] [Abstract].
  4. "hPWP1-interacting proteins 2 and 11 (Tax-interacting protein 1)."Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  7. "The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element."J. Biol. Chem. 275:33962-33968(2000) [PubMed] [Europe PMC] [Abstract]
  8. "TIP-1 has PDZ scaffold antagonist activity."Mol. Biol. Cell 17:4200-4211(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42."Br. J. Cancer 104:324-331(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the human Tax-interacting protein-1."J. Biomol. NMR 45:329-334(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1."J. Mol. Biol. 392:967-976(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The structure of the PDZ domain of TAX1BP."Submitted (FEB-2009) to the PDB data bank
  18. "Promiscuous binding at the crossroads of numerous cancer pathways: insight from the binding of glutaminase interacting protein with glutaminase L."Biochemistry 50:3528-3539(2011) [PubMed] [Europe PMC] [Abstract]