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GATA Zinc Finger Domain Containing Protein 2B (GATAD2B)

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P66beta; p66/p68; Transcription Repressor p66 Beta Component Of The MeCP1 Complex; Transcriptional repressor p66-beta

GATA Zinc Finger Domain Containing Protein 2B (GATAD2B)
CCC S202
HGNC 30778
MGI 2443225
PubMed 23644463
RGD 1308533
UniProt Q8WXI9
Wiki GATAD2B
Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes. A major biological consequence of DNA methylation is gene silencing. Increasing evidence indicates that recruitment of histone deacetylase complexes by methyl-CpG-binding proteins is a major mechanism of methylated DNA silencing. To understand the molecular mechanism of the functioning of the MeCP1 complex, the individual components of the MeCP1 complex need to be characterized. Analysis of the p66 homologs from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Zinc Finger Domain Containing Protein 2B (GATAD2B) ELISA Kit Customized Service Offer
  1. "Identification and functional characterization of the p66/p68 components of the MeCP1 complex."Mol. Cell. Biol. 22:536-546(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3."J. Biol. Chem. 277:40958-40966(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction."Nucleic Acids Res. 34:397-406(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila." J. Med. Genet. 50:507-514(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]