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Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B)

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ACSM2; HXMA; Xenobiotic/Medium Chain Fatty Acid:CoA Ligase; Middle-chain acyl-CoA synthetase 2B; Butyrate--CoA ligase 2B

Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B)
CCC S226
HGNC 30931
PubMed 12616642
UniProt Q68CK6
Wiki ACSM2B
The purification of xenobiotic/medium-chain fatty acid:CoA ligases (XM-ligases) from human liver mitochondria resulted in the isolation of two chromatographically separable forms (HXM-A and HXM-B). Identical sequences were obtained for HXM-A and HXM-B for the two peptides. These sequences were used to design probes for screening a human liver cDNA library. This resulted in the isolation of two overlapping cDNAs. This protein bears 56.2% amino acid homology to the MACS1 (medium-chain acyl-CoA synthetase) enzyme, 58.7% homology to the bovine XL-III XM-ligase, and 81.5% homology to the bovine XL-I XM-ligase. The cDNA could be expressed in COS cells, and the expressed enzyme had greater benzoate activity than phenylacetate activity, which is consistent with the known substrate specificity of HXM-A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Synthetase Medium Chain Family, Member 2B (ACSM2B) ELISA Kit Customized Service Offer
  1. "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria."J. Biochem. Mol. Toxicol. 17:1-6(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids."Biochim. Biophys. Acta 1428:455-462(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines."Biochem. Genet. 47:739-748(2009) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]