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Zinc Finger Protein 42 Homolog (ZFP42)

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REX1; ZNF754; Reduced expression protein 1

Zinc Finger Protein 42 Homolog (ZFP42)
CCC S228
HGNC 30949
MGI 99187
PubMed 18433507
UniProt Q96MM3
Wiki ZFP42
Rex1/Zfp42 has been extensively used as a marker for the undifferentiated state of pluripotent stem cells. However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in visceral endoderm differentiation in F9 embryonal carcinoma (EC) cells was reported.
Rex1 function is dispensable for both the maintenance of pluripotency in ES cells and the development of embryos. However, Rex1-/- ES cells showed the defect to induce a subset of the marker genes of visceral endoderm, when differentiated as embryoid body, as found in EC cells. Rex1 should be regarded just as a marker of pluripotency without functional significance like the activity of alkaline phosphatase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 42 Homolog (ZFP42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 42 Homolog (ZFP42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 42 Homolog (ZFP42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 42 Homolog (ZFP42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 42 Homolog (ZFP42) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 42 Homolog (ZFP42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 42 Homolog (ZFP42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 42 Homolog (ZFP42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 42 Homolog (ZFP42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 42 Homolog (ZFP42) ELISA Kit Customized Service Offer
  1. "Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens."Stem Cells 20:329-337(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors."Cancer Res. 66:820-827(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma."Carcinogenesis 27:499-507(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures."Mol. Carcinog. 45:887-900(2006) [PubMed] [Europe PMC] [Abstract]