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MAFF Interacting Protein (MAFIP)

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MIP; Tektin-4 like protein PP5644

MAFF Interacting Protein (MAFIP)
CCC S237
HGNC 31102
PubMed 21834855
UniProt Q8WZ33
The human transcription factor MafF (hMafF) lacks a transactivation domain, it contains a heptad-leucine repeat motif (viz., Leu-zipper) that may mediate protein-protein interactions to regulate transcriptional activities. A protein with a coiled-coil domain encoded by a novel human gene (GenBank Accession No. AF289559) was found to interact with hMafF in vitro and in vivo and is designated as a MafF interacting protein (MIP).
Expression of hMafF or MIP alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP activated transcription efficiently. Moreover, truncated MIP, still containing the coiled-coil domain, transactivated as well as the full-length MIP did, and highlighting that MIP acts as a co-activator of hMafF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAFF Interacting Protein (MAFIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAFF Interacting Protein (MAFIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAFF Interacting Protein (MAFIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAFF Interacting Protein (MAFIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAFF Interacting Protein (MAFIP) ELISA Kit Customized Service Offer
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  2. "PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1."Mol. Cell. Biochem. 271:151-158(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The novel human gene MIP functions as a co-activator of hMafF."Arch. Biochem. Biophys. 449:87-93(2006) [PubMed] [Europe PMC] [Abstract]