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Neurobeachin Like Protein 2 (NBEAL2)

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Neurobeachin Like Protein 2 (NBEAL2)
CCC S281
HGNC 31928
MGI 2448554
PubMed 21765413
RGD 1306501
UniProt Q6ZNJ1
Wiki NBEAL2
NBEAL2, Belongs to the WD repeat neurobachin family. Neurobeachin is a 327 kDa protein found predominantly in neural tissues. Neurobeachin is a protein containing a BEACH (beige and Chediak-Higashi) domain implicated in synaptic vesicle trafficking and an AKAP (A-kinase anchor protein) domain linked to localization of cAMP-dependent protein kinase activity. nbea-null mice demonstrated a complete block of evoked synaptic transmission at neuromuscular junctions, whereas nerve conduction, synaptic structure, and spontaneous synaptic vesicle release were completely normal. These findings support an essential role for Neurobeachin in evoked neurotransmitter release at neuromuscular junctions and suggest that it plays an important role in synaptic transmission.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurobeachin Like Protein 2 (NBEAL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurobeachin Like Protein 2 (NBEAL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurobeachin Like Protein 2 (NBEAL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurobeachin Like Protein 2 (NBEAL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurobeachin Like Protein 2 (NBEAL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurobeachin Like Protein 2 (NBEAL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurobeachin Like Protein 2 (NBEAL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurobeachin Like Protein 2 (NBEAL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurobeachin Like Protein 2 (NBEAL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurobeachin Like Protein 2 (NBEAL2) ELISA Kit Customized Service Offer
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  7. "NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet alpha-granules." Nat. Genet. 43:732-734(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome."Nat. Genet. 43:735-737(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome." Nat. Genet. 43:738-740(2011) [PubMed] [Europe PMC] [Abstract]