Zinc Finger Protein 737 (ZNF737)

ZNFs, which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. The C2H2 ZNF family is characterized by repeated zinc finger motifs of approximately 28 amino acids that chelate a zinc ion using 2 cysteine residues and 2 histidine residues.

By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF737, which they called ZNF102. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.