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Sperm Associated Antigen 11A (SPAG11A)

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HE2; EP2; EDDM2A; Epididymal Protein 2A; Human epididymis-specific protein 2

Sperm Associated Antigen 11A (SPAG11A)
CCC S369
HGNC 33342
PubMed 9739419
UniProt Q6PDA7
Defensins are short, processed peptide molecules that are classified into three different structural groups: alpha-defensins, beta-defensins and theta-defensins. Much interest has been focused on the genetic variation in defensin loci present in the human population, as this may be a key in understanding individual differences in disease susceptibility and severity. The defensin genes are located on 8p23-p22.
Also of interest is the SPAG11A gene, which is located about 17 kb upstream from the defensin genes. SPAG11A encodes for proteins with an antibacterial activity which affect sperm maturation. The SPAG11A gene is 19 kb long - including 3 kb of proximal promoter region - and contains 8 exons and 2 promoters. It is thought that SPAG11A is derived from ancestral beta-defensin genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 11A (SPAG11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 11A (SPAG11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 11A (SPAG11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 11A (SPAG11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 11A (SPAG11A) ELISA Kit Customized Service Offer
  1. "HE2 beta and HE2 gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human."Endocrinology 141:1245-1253(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes."Biol. Reprod. 64:1072-1079(2001) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]