≡

Glutathione S Transferase Theta 2B (GSTt2B)

[Edit]

GSTT2P; GST class-theta-2

Glutathione S Transferase Theta 2B (GSTt2B)
CCC S372
HGNC 33437
PubMed 22216261
UniProt P0CG30
The structure and organization of the human Theta-class glutathione S-transferase (GST) genes have been determined. GSTT1 and GSTT2 are separated by approx. 50 kb. They have a similar structure, being composed of five exons with identical exon/intron boundaries. GSTT1 is 8.1 kb in length, while GSTT2 is only 3.7 kb. The GSTT2 gene lies head-to-head with a gene encoding d-dopachrome tautomerase (DDCT), which extends over 8.5 kb and contains four exons. The sequence between GSTT2 and DDCT may contain a bidirectional promoter. The GSTT2 and DDCT genes have been duplicated in an inverted repeat. Sequence analysis of the duplicated GSTT2 gene has identified an exon 2/intron 2 splice site abnormality and a premature translation stop signal at codon 196. These changes suggest that the duplicate gene is a pseudogene, and it has been named GSTT2P.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione S Transferase Theta 2B (GSTt2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione S Transferase Theta 2B (GSTt2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione S Transferase Theta 2B (GSTt2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione S Transferase Theta 2B (GSTt2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Theta 2B (GSTt2B) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22."Genomics 25:381-387(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a human class-theta glutathione S-transferase with activity towards 1-menaphthyl sulphate."Biochem. J. 286:929-935(1992) [PubMed] [Europe PMC] [Abstract]
  6. "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human."Biochem. J. 318:297-303(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site."Structure 6:309-322(1998) [PubMed] [Europe PMC] [Abstract]