POTE Ankyrin Domain Family, Member F (POTEF)

POTE is expressed in many cancers but in a limited number of normal organs. The 13 POTE genes are dispersed among eight different chromosomes and evolved by duplications and remodeling of the human genome from an ancestral gene, ANKRD26. Based on sequence similarity, the POTE gene family members can be divided into three groups.

The protein encoded by the POTE-actin transcript is predicted to be 120 kDa in size. Evolution and expression of chimeric POTE-actin genes in the human genome. 120-kDa POTE-actin fusion protein in breast cancer cell lines known to express the fusion transcript. These data demonstrate that insertion of a retroposon produced an altered functional POTE gene. This example indicates that new functional human genes can evolve by insertion of retroposons.