Cadherin Related Family, Member 4 (CDHR4)

CDHR4, Contains 4 cadherin domains. The cadherin superfamily includes cadherins, protocadherins, desmogleins, and desmocollins, and more. In structure, they share cadherin repeats, which are the extracelular Ca²⁺-binding domains. There are multiple classes of cadherin molecule, each designated with a prefix. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. For example, cells containing N-cadherin tend to cluster with other N-cadherin expressing cells. However, it has been noted that the mixing speed in the cell culture experiments can have an effect on the extent of homotypic specificity. In addition, several groups have observed heterotypic binding affinity in various assays.