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T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2)

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Tim2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2

T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2)
CCC S573
MGI 2159681
PubMed 16328331
RGD 1359571
UniProt Q8R183
TIMD2, Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. T cells on activation differentiate into different subsets (Th1 or Th2) with distinct effector functions. These T cell subsets are primarily differentiated on the basis of the cytokines that they produce, a novel gene family called TIM (T cell, immunoglobulin, mucin domain-containing molecules), whose members are differentially expressed on Th1 and Th2 cells. Three of the family members (Tim-1, Tim-3, and Tim-4) are conserved between mouse and man. Genomic association of the TIM family and polymorphisms in both Tim-1 and Tim-3 in different immune-mediated diseases suggest that the family may have an important role in regulating immunity, both in terms of normal immune responses and in diseases like autoimmunity and asthma.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Immunoglobulin And Mucin Domain Containing Protein 2 (TIMD2) ELISA Kit Customized Service Offer
  1. "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family."Nat. Immunol. 2:1109-1116(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2."Nature 419:629-633(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family."Immunity 26:299-310(2007) [PubMed] [Europe PMC] [Abstract]