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RNA Exonuclease 1 Like Protein 1 (REXO1L1)

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GOR

RNA Exonuclease 1 Like Protein 1 (REXO1L1)
CCC S607
HGNC 24660
UniProt Q8IX06
A hydrolyzing reaction that breaks phosphodiester bonds at either the 3’ or the 5’ end occurs. Its close relative is the endonuclease, which cleaves phosphodiester bonds in the middle of a polynucleotide chain.In both archaebacteria and eukaryotes, one of the main routes of RNA degradation is performed by the multi-protein exosome complex, which consists largely of 3' to 5' exoribonucleases. Exonuclease GOR is a 675 amino acid protein belonging to the REXO1/REXO3 family.It has been suggested that the anti-GOR response is closely related to HCV infection and may reflect an HCV-associated autoimmune phenomenon. HCV capsid proteins initiate the autoimmune process in the liver because of cross reaction of antibodies with human Gor protein 19-27, which causes autoimmune chronic hepatitis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Exonuclease 1 Like Protein 1 (REXO1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Exonuclease 1 Like Protein 1 (REXO1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Exonuclease 1 Like Protein 1 (REXO1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Exonuclease 1 Like Protein 1 (REXO1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Exonuclease 1 Like Protein 1 (REXO1L1) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The GOR gene product cannot cross-react with hepatitis C virus in humans."Clin. Exp. Immunol. 124:429-434(2001) [PubMed] [Europe PMC] [Abstract]