Neuropeptide Y Receptor Y6 (NPY6R)

The rabbit Y2b receptor encodes a functional 371-amino acid protein, the human ortholog contains a premature stop codon, resulting in a 290-amino acid protein which has no receptor function. All primates tested had a truncated Y2b gene product, some having a second premature stop codon, thus encoding an even shorter polypeptide than the human. Northern blot analysis revealed that the Y2b gene is abundantly expressed in human heart and skeletal muscle as a 3-kb transcript.Sequence analysis of the human PP2 gene indicated that it encodes a 290-amino acid polypeptide with one difference when compared to the mouse ortholog and to other NPY receptors: all human PP2 clones examined contained a single basepair deletion relative to the mouse ortholog, resulting in a truncated protein lacking the seventh transmembrane domain.