Peroxisome Proliferator Activated Receptor Beta (PPARb)

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CCC	S640
PubMed	17380536
UniProt	C4B6E1

is only weakly activated by fatty acids, prostaglandins and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer

A role for the nuclear receptor peroxisome proliferator-activated receptor-b (PPARb) in oncogenesis has been suggested by a number of observations but its precise role remains elusive. Prostaglandin I2 (PGI2,prostacyclin), a major arachidonic acid (AA) derived cyclooxygenase (Cox) product, has been proposed as a PPARb agonist. Surprisingly, however, 4-OHT failed to activate PPARb transcriptional activity,indicating that PGI2 is insufficient for PPARb activation. Conversely, inhibition of PGIS blocked PGI2 synthesis but did not affect the AA mediated activation of PPARb.

Organism species: Danio rerio (Zebrafish)

	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	n/a	Recombinant Peroxisome Proliferator Activated Receptor Beta (PPARb)	Recombinant Protein Customized Service Offer
Antibodies	n/a	Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Beta (PPARb)	Monoclonal Antibody Customized Service Offer
Antibodies	n/a	Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Beta (PPARb)	Polyclonal Antibody Customized Service Offer
Assay Kits	n/a	CLIA Kit for Peroxisome Proliferator Activated Receptor Beta (PPARb)	CLIA Kit Customized Service Offer
Assay Kits	n/a	ELISA Kit for Peroxisome Proliferator Activated Receptor Beta (PPARb)	ELISA Kit Customized Service Offer

"Transcriptional activities of medaka Oryzias latipes peroxisome proliferator-activated receptors and their gene expression profiles at different temperatures."Fish. Sci. 76:167-175(2010)