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ATP/GTP Binding Protein Like Protein 3 (AGBL3)

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CCP3; Cytosolic carboxypeptidase 3

ATP/GTP Binding Protein Like Protein 3 (AGBL3)
CCC S663
HGNC 27981
MGI 1923473
RGD 1561995
UniProt Q8NEM8
AGBL3, Belongs to the peptidase M14 family, May play a role in the processing of tubulin. Nna1/CCP1, CCP2, CCP5, and CCP6 were found to exhibit a cytosolic distribution, with a slight accumulation of CCP5 in the nucleus. Nna1/CCP1 and CCP2–6 function in the processing of cytosolic proteins such as alpha-tubulin, which is known to be modified by the removal of a C-terminal tyrosine.
Analysis of the forms of alpha tubulin in the olfactory bulb of mice lacking Nna1/CCP1 showed the absence of the detyrosinylated form in the mitral cells. Taken together, these results are consistent with a role for Nna1/CCP1 and the related CCPs in the processing of tubulin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 3 (AGBL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 3 (AGBL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 3 (AGBL3) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 3 (AGBL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 3 (AGBL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 3 (AGBL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 3 (AGBL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 3 (AGBL3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily."FASEB J. 21:851-865(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids."Mol. Biol. Cell 25:3017-3027(2014) [PubMed] [Europe PMC] [Abstract]