N-Acetyltransferase 3 (NAT3)
Rat Nat3 amino acid sequence was 68.6% and 67.2% identical to human NAT1 and NAT2, respectively. Rat Nat1, Nat2, and Nat3 were each cloned and recombinantly expressed in Escherichia coli. Recombinant rat Nat3 exhibited thermostability intermediate between recombinant rat Nat1 and Nat2. Recombinant rat Nat3 was functional and catalyzed the N-acetylation of several arylamine substrates, including 3-ethylaniline, 3,5-dimethylaniline, 5-aminosalicylic acid, 4-aminobiphenyl, 4,4′-methylenedianiline, 4,4′-methylenebis(2-chloroaniline), and 2-aminofluorene, and the O-acetylation of N-hydroxy-4-aminobiphenyl. The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and 2-aminofluorene for N-and O-acetylation via recombinant rat Nat3 were comparable to recombinant rat Nat1 and higher than for recombinant rat Nat2.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 3 (NAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 3 (NAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 3 (NAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetyltransferase 3 (NAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetyltransferase 3 (NAT3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 3 (NAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 3 (NAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 3 (NAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetyltransferase 3 (NAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetyltransferase 3 (NAT3) ELISA Kit Customized Service Offer
  1. "Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice."Pharmacogenetics 12:385-394(2002) [PubMed] [Europe PMC] [Abstract], , and .