≡

MutL Homolog 2 (MLH2)

[Edit]

DNA mismatch repair protein MLH2

MutL Homolog 2 (MLH2)
CCC S699
PubMed 12584170
UniProt Q07980
Loss of MLH2 resulted in a small but significant decrease in spore viability and a significant increase in gene conversion frequencies but had no apparent effect on crossing over. Deletion of MLH2 in mlh3Delta, msh4Delta or msh5Delta strains resulted in significant proportion of the "lost" crossovers found in single deletion strains being regained in some genetic intervalsthere are at least two pathways to generate crossovers in yeast .
Most recombination intermediates are processed by the "major", Msh4-dependent pathway, which requires the activity of Mlh1p/Mlh3p/Msh4p/Msh5p as well as a number of other proteins. The minor pathway(s) utilizes Mms4p/Mus81p. the absence of Mlh2p allows some crossovers from the MSH4 pathway to traverse the MUS81-dependent pathway.

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutL Homolog 2 (MLH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutL Homolog 2 (MLH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutL Homolog 2 (MLH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutL Homolog 2 (MLH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutL Homolog 2 (MLH2) ELISA Kit Customized Service Offer
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The reference genome sequence of Saccharomyces cerevisiae: Then and now."G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
  3. "Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction."Proc. Natl. Acad. Sci. U.S.A. 96:13914-13919(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast."Curr. Biol. 10:145-148(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Global analysis of protein localization in budding yeast."Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global analysis of protein expression in yeast."Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast."Cytogenet. Genome Res. 107:180-190(2004) [PubMed] [Europe PMC] [Abstract]