Mitogen Activated Protein Kinase Activated Protein Kinase 1 (MAPKAPK1)

MAPKAPK1 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90^rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70^rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90^rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway.