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Mediator Complex Subunit 2 (MED2)

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Mediator of RNA polymerase II transcription subunit 2

Mediator Complex Subunit 2 (MED2)
CCC S709
PubMed 14988503
UniProt Q12124
MED2 belongs to the mediator complex subunit 2 family. The yeast Mediator complex is required for transcriptional regulation both in vivo and in vitro, and its function is conserved in all eukaryotes. Mediator interacts with both transcriptional activators and RNA polymerase II, but little is known about the mechanisms by which it operates at the molecular level.The cyclin-dependent kinase Srb10 interacts with, and phosphorylates, the Med2 subunit of Mediator both in vivo and in vitro. A point mutation of the single phosphorylation site in Med2 results in a strongly reduced expression of the REP1, REP2, FLP1, and RAF1 genes, which are all located on the endogenous 2-microm plasmid. Combined with previous studies on the effects of SRB10/SRB11 deletions, Posttranslational modifications of Mediator subunits are important for regulation of gene expression.

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 2 (MED2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 2 (MED2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 2 (MED2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 2 (MED2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 2 (MED2) ELISA Kit Customized Service Offer
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