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Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4)

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HLA-DRB4; HLA-DR4B; HLADRb4; HLA class II histocompatibility antigen, DR beta 4 chain

Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4)
CCC S712
HGNC 4952
UniProt P13762
Wiki HLA-DRB4
HLA-DRB4 is a genetic risk factor for the development of CSS and increases the likelihood of development of vasculitic manifestations of the disease. The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DR Beta 4 (MHCDRb4) ELISA Kit Customized Service Offer
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