≡

LSM10 Homolog (LSM10)

[Edit]

U7 snRNA-associated Sm-like protein LSm10

LSM10 Homolog (LSM10)
CCC S722
HGNC 17562
MGI 2151045
PubMed 11574479
RGD 1584914
UniProt Q969L4
Wiki LSM10
LSM10 is a 14 kDa polypeptide that is a member of the Sm/Lsm protein family. Like U7 snRNA, LSM10 is enriched in Cajal or coiled bodies (CBs) in the nucleus. LSM10 associates with the U7 snRNP and this interaction is dictated by the special Sm binding site of U7 snRNA.
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM10 Homolog (LSM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM10 Homolog (LSM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM10 Homolog (LSM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM10 Homolog (LSM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM10 Homolog (LSM10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM10 Homolog (LSM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM10 Homolog (LSM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM10 Homolog (LSM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM10 Homolog (LSM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM10 Homolog (LSM10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM10 Homolog (LSM10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM10 Homolog (LSM10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM10 Homolog (LSM10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM10 Homolog (LSM10) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM10 Homolog (LSM10) ELISA Kit Customized Service Offer
  1. "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]
  4. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]