Rheic Acid (Rhein)

Rhein,is a substance in the anthraquinone group obtained from rhubarb. Like all such substances, rhein is a cathartic. Rhein is commonly found as a glycoside such as rhein-8-glucoside or glucorhein. Originally the rhubarb plant which contains rhein was used as a laxative. It was believed that rhein along with other anthraquinone glycosides imparted this activity. Rhein has been reevaluated as an antibacterial agent against Staphylococcus aureus in 2008. Synergy or partial synergy has been demonstrated between rhein and the antibiotics oxacillin and ampicillin. The pharmacokinetics of rhein have not been intensively studied in humans, but at least one study in healthy male volunteers found that rhein was better absorbed from oral administration of rhubarb than from a retention enema. Rhein was shown to be safe when administered for five days to elderly patients with chronic congestive heart failure.