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COMM Domain Containing Protein 8 (COMMD8)

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COMM Domain Containing Protein 8 (COMMD8)
CCC S847
HGNC 26036
MGI 1343485
PubMed 23563313
RGD 1305402
UniProt Q9NX08
COMMD8, Contains 1 COMM domain. In additition to COMMD1, COMMD2, COMMD8 and COMMD10, but not the other COMMD proteins directly interact with the WD protein ATP7B, suggesting that these proteins might function in the regulation of copper homeostasis.
Eight known polymorphisms, but no mutations in the COMMD2, COMMD8 and COMMD10 genes, including the exon-intron boundaries, were identified in a total of 18 patients with non-Wilsonian hepatic copper toxicosis. COMMD2, COMMD8 and COMMD10 directly interact with the WD protein ATP7B, but their involvement in the pathogenesis of non-Wilsonian hepatic copper toxicosis appears unlikely.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 8 (COMMD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 8 (COMMD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 8 (COMMD8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 8 (COMMD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 8 (COMMD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 8 (COMMD8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 8 (COMMD8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 8 (COMMD8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 8 (COMMD8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 8 (COMMD8) ELISA Kit Customized Service Offer
  1. "COMMD proteins, a novel family of structural and functional homologs of MURR1."J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."J. Biol. Chem. 286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."Am. J. Physiol. 305:F80-F89(2013) [PubMed] [Europe PMC] [Abstract]
  7. "CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling."J. Clin. Invest. 123:2244-2256(2013) [PubMed] [Europe PMC] [Abstract]
  8. "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A." Mol. Biol. Cell 26:91-103(2015) [PubMed] [Europe PMC] [Abstract]